Bioactivity | [Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist. | ||||||
Target | NK1 receptor | ||||||
Invitro | [Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1]. | ||||||
Name | [Sar9,Met(O2)11]-Substance P TFA | ||||||
Sequence | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2 | ||||||
Shortening | RPKPQQFF-{Sar}-LM[O2]-NH2 | ||||||
Formula | C66H101N18F3O17S | ||||||
Molar Mass | 1507.68 | ||||||
Appearance | Solid | ||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||
Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
||||||
Reference | [1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28. |